DEC 2013

EyeWorld is the official news magazine of the American Society of Cataract & Refractive Surgery.

Issue link: https://digital.eyeworld.org/i/227001

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December 2013 His team plans on reproducing the whole process with human embryonic stem cells. "That's the next stage before we can start to think about taking this into a clinical trial and seeing whether we can restore vision in patients who have lost photoreceptors," he said. However, a clinical trial on this is at least five years away. Also, while to date most of the work has been focused on rod transplantation, simply because this is easier, Dr. Ali thinks that the emphasis going forward will likely shift to cones. For macular degeneration, replacing a relatively few cones might be highly effective, he said. "You only have 200,000 cones (in the eye), and in the fovea, which you need for central vision, you have 20,000 cones," Dr. Ali said. "We could have a high impact by transplanting a relatively few cells— that's what we would like to investigate." EW Editors' note: Dr. Ali has no financial interests related to this article. Source: Colin Chu 51 Contact information Ali: 44-207-608-4023, R.ali@ucl.ac.uk Save the Date! Saturday, April 26, 2014 7:00 – 9:30 AM 2014 ASCRS ASOA Symposium & Congress 3D reconstruction of a transplanted photoreceptor (green) generated from 3D culture of embryonic stem cells. The newly integrated cell resembles a typical rod photoreceptor. EW RETINA Boston Convention and Exhibition Center www.eyeworld.org CME credit is not available for Corporate Mornings programs.

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