I
INNOVATIONS IN LENSES
N FOCUS
100 | EYEWORLD | APRIL 2019
Contact
information
Berdahl: johnberdahl@gmail.com
Chang: dceye@earthlink.net
MacRae:
scott_macrae@urmc.rochester.edu
Mamalis:
nick.mamalis@hsc.utah.edu
Werner:
Liliana.werner@hsc.utah.edu
Zheleznyak:
lzheleznyak@cleriovision.com
refractive error, such as sphere and cylinder." It is
also possible to induce and remove multifocality
and correct the eye's higher order aberrations.
The LIRIC approach is under development
for compatibility with a range of widely used
IOLs. It also can be used with the cornea and
contact lenses.
Scott MacRae, MD, presented information at
the 2019 Hawaiian Eye Meeting about the first-
in-human study of corneal LIRIC. A total of 27
eyes have had the LIRIC approach for presbyopia
correction. No degradation of far vision oc-
curred, and there was a significant improvement
in intermediate and a moderate improvement for
near vision after LIRIC, Dr. MacRae said.
"We demonstrated the writing of diffractive
optics into the corneal stroma of subjects im-
planted with monofocal IOLs," Dr. Zheleznyak
said. "We expect this procedure to be followed by
a version of LIRIC where the LIRIC patterns can
be written directly into the IOL instead of into
the cornea."
Studies with LIRIC are still underway. Dr.
Zheleznyak anticipates that it will be available
commercially in late 2022 or early 2023.
that same IOL back into a monofocal if neces-
sary. "It can also cancel the diffractive multifocal
add of a traditional IOL, all without significant
changes to the IOL optic quality," Dr. Werner
said.
Drs. Werner and Mamalis have published
studies related to the Perfect Lens technology.
"What I find impressive is that it's extremely
precise," Dr. Mamalis said. "In the lab, when
we're changing the power of a lens, it's accurate to
one-tenth of a diopter of a correction." In rabbit
studies, there have been no signs of inflammation
after corrections or any problems with toxicity
when examining the histopathology, he said.
Current studies of the Perfect Lens technol-
ogy have been done in the lab, but clinical studies
should start relatively soon, Dr. Mamalis said.
LIRIC
Clerio Vision introduced an approach called
laser induced refractive index change (LIRIC).
"Laser induced refractive index change works by
focusing a femtosecond laser beam into the IOL
material," said Len Zheleznyak, PhD. "Within the
laser focus, the native refractive index of the IOL
material is adjusted by a predetermined amount.
With this technology, it is possible to correct
Dr. MacRae performs the first-in-human study of corneal LIRIC. Pseudophakic patients with monofocal IOLs were treated
with a diffractive multifocal refractive index wavefront in the corneal stroma.
Source: Clerio Vision
continued from page 99
Financial interests
Berdahl: RxSight
Chang: Perfect Lens, RxSight
Mamalis: Perfect Lens
MacRae: Clerio Vision
Werner: Perfect Lens
Zheleznyak: Clerio Vision
