Eyeworld

123 EW CORNEA March 2018 normal process of donor evaluation, it doesn't withstand the stress of the longest preservation time and fails early on. "There's a subset, which we can't detect with our current methods for donor evaluation, that could not withstand that stress," Dr. Lass said. A separate analysis of cell loss led by Dr. Lass likewise boded well for tissue preserved for lon- ger periods. 2 At the 3-year mark, investigators found that this was comparable in the 0- to 7-day pres- ervation group and the 8- to 14-day one. "But again, we found that the longest group had more cell loss of clear grafts in 3 years than the shorter group did," Dr. Lass said, adding that there was 37% cell loss compared to baseline for the shorter group versus a 40% loss in the lon- ger group. Once again, when a subgroup analysis was done, it was deter- mined that most of the cell loss was coming in that longest preserva- tion group, particularly at day 14. "Again, this supported the findings that it was fine to go out 11 to 12 days," he said. "It suggests that the preservation time had an effect on the ones that are surviving at 3 years." This means that it may be necessary to follow these eyes a little longer in order to determine if there are going to be any more late fail- ures in the ones that were preserved for 13 or 14 days. Dr. Lass hopes that practitioners come away from this with a new confidence in using donor corneas that have been preserved for up to 11 days. "There's no difference," he said. The hope is to change people's minds and increase the average preservation time in the U.S. from 7–8 days and move it more toward 10–11 days. "This is going to help eye banks now and in the future as the demand for corneas is going to increase with an aging population," Dr. Lass said. EW References 1. Rosenwasser GO, et al. Effect of cornea preservation time on success of Descemet stripping automated endothelial keratoplasty: a randomized clinical trial. JAMA Ophthalmol- ogy. 2017;135:1401–1409. 2. Lass JH, et al. Corneal endothelial cell loss 3 years after successful Descemet stripping automated endothelial keratoplasty in the Cornea Preservation Time Study: a ran- domized clinical trial. JAMA Ophthalmology. 2017;135:1394–1400. Editors' note: Dr. Lass has no financial interests related to his comments. Contact information Lass: Jonathan.Lass@UHhospital.org The gold standard, now with axial length measurement – versatile, profitable, indispensable! Once again, the Pentacam® defines the "measure of all things." The AXL version, featuring integrated optical biometry, makes it a comprehensive, indispensable instrument for cataract surgery. As a full-scale system, the Pentacam® AXL also provides for safe and swift IOL calculation – even in difficult cases. Visit www.pentacam.com for more information. Now Available! The OCULUS Pentacam ® AXL Always an Axial Length Ahead Follow us! Toll free 888- 519 - 5375 sales@oculususa.com www.oculususa.com

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