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EW FEATURE 56 10. Moloney G, et al. Descemetorhexis for Fuchs' dystrophy. Can J Ophthalmol. 2015;50:68–72. 11. Moloney G, et al. Descemetorhexis without grafting for Fuchs' endothelial dystrophy– supplementation with topical ripasudil. Cornea. 2017;36:642–648. 12. Peh GS, et al. Cultivation of human corneal endothelial cells isolated from paired donor corneas. PLoS One. 2011;6:e28310. 13. Numata R, et al. Cultivation of corneal endothelial cells on a pericellular matrix pre- pared from human decidua-derived mesen- chymal cells. PLoS One. 2014;9:e88169. 14. Mimura T, et al. Treatment of rabbit bul- lous keratopathy with precursors derived from cultured human corneal endothelium. Invest Ophthalmol Vis Sci. 2005;46:3637–44. 15. Tan TE, et al. A cost-minimization analysis of tissue-engineered constructs for corne- al endothelial transplantation. PLoS One. 2014;9:e100563 16. Bhogal M, et al. Allogeneic Descemet's membrane transplantation enhances corneal endothelial monolayer formation and restores functional integrity following Descem- et's stripping. Invest Ophthalmol Vis Sci. 2017;58:4249–4260. Editors' note: Dr. Mehta has a patent on the culture media used for culti- vation of human corneal endothelial cells. Dr. Agarwal and Dr. Colby have no financial interests related to their comments. Contact information Agarwal: dragarwal@vsnl.com Colby: kcolby@bsd.uchicago.edu Mehta: jodmehta@gmail.com Alternative continued from page 54 800.354.7848 TOLL FREE IN THE USA | +1.859.259.4924 WORLD WIDE | stephensinst.com S9-2070 S9-2060 S9-2065 As we celebrate 40 years of service to the ophthalmic community, we recognize those doctors who have grown along with us. Just like our instruments, our reputation for value, service and reliability has been crafted to last a lifetime. "I have used Stephens ophthalmic instruments since I went into practice—forty years ago. When I need new microsurgical instruments, I look to Stephens first." JOHN E. DOWNING, MD Bowling Green, Kentucky © 2017 Stephens Instruments. All rights reserved. the donor Descemet's, which is acting as a scaffold but also pre- vents stromal cell migration to the posterior. Dr. Mehta said replacing with an acellular Descemet's rather than stripping and leaving without a graft resulted in better recovery in a rabbit host. 16 EW References 1. Terry MA. Endothelial keratoplasty: history, current state, and future directions. Cornea. 2006;25:873–8. 2. Gain P, et al. Global survey of corneal trans- plantation and eye banking. JAMA Ophthal- mol. 2016;134:167–73. 3. Agarwal A, et al. Pre-Descemet endothelial keratoplasty with infant donor corneas: a pro- spective analysis. Cornea. 2015;34:859–65. 4. Agarwal A. Pre-Descemet's endothelial keratoplasty (PDEK). New Delhi, India. Jaypee Brothers Medical Publishers. November 2017. 5. Balachandran C, et al. Spontaneous corneal clearance despite graft detachment in De- scemet membrane endothelial keratoplasty. Am J Ophthalmol. 2009;148:227–234. 6. Arbelaez JG, et al. Long-term follow-up and complications of stripping Descemet membrane without placement of graft in eyes with Fuchs' endothelial dystrophy. Cornea. 2014;33:1295–9. 7. Koenig SB. Planned Descemetorhexis without endothelial keratoplasty in eyes with Fuchs' corneal endothelial dystrophy. Cornea. 2015;34:1149–51. 8. Okumara N, et al. Effect of the rho-asso- ciated kinase inhibitor eye drop (ripasudil) on corneal endothelial wound healing. Invest Ophthalmol Vis Sci. 2016;57:1284–92. 9. Borkar DS, et al. Treatment of Fuchs' endothelial dystrophy by Descemet stripping without endothelial keratoplasty. Cornea. 2016;35:1267–73. All you need to know about cornea transplants • January 2018 Corneas of rabbits receiving tissue engineered graft in tissue engineered endothelial keratoplasty group swelled to almost 1,000 μm by day 4. Corneal thickness recovered to just under 400 μm by week 3. Corneas of rabbits receiving dose of corneal endothelial cell injection increased in corneal thickness slightly at day 4, but gradually thinned down to just under 500 μm thick by week 3. Control rabbit corneas had thickness of about 400 μm–425 μm and did not cross-react when stained with anti-human nuclei antibody. Source: Jodhbir Mehta, MD

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