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EW NEWS & OPINION February 2016 27 death: an animal model. Biomed Res Int. 2015:627201. 3. Locci E, et al. A metabolomic approach to animal vitreous humor topographi- cal composition: a pilot study. PLoS One. 2014;9(5):e97773. "The cortical area was character- ized by lactate, glutamine, choline, and its derivatives, N-acetyl groups, creatine, and glycerol; the core area was characterized by glucose, acetate, and scyllo-inositol; and the basal area was characterized by branched-chain amino acids (BCAA), betaine, alanine, ascorbate, lysine, and myo-inositol," the research team reported. The results, Locci and colleagues emphasized, highlighted a well- known issue in the ophthalmic field: There is more to the role of the vitreous that far exceeds oculogen- esis and protection in ocular health and disease. What lies ahead? Hence, the potential impact of the recent establishment of the com- position of the human vitreous is boundless. According to the team from SAIO, their data may provide not just normal baseline to facilitate subsequent studies characterizing the changes that occur to the vitre- ous profile during disease, but also baseline data to help forensic pa- thologists determine time of death from vitreous biopsies, validation for future spectroscopic determination of vitreous biochemistry, and the motivation to develop more physio- logical intravitreal irrigating solu- tions and vitreous substitutes. "We anticipate our results will eventually guide the production of more physiological, personalized vitreous humour substitutes," Dr. Kokavec said. "Our results will also provide a reference point for future applica- tions such as noninvasive vitreoret- inal analysis via Raman spectrosco- py," he added. Furthermore, research work at the Hanson Institute and South Australian Institute of Ophthalmol- ogy, Dr. Kokavec said, have already identified that increased vitreous glucose concentrations induce tem- porary functional recovery of retinal ganglion cells affected by primary open-angle glaucoma. "Our vitreous biochemistry findings will be used to develop new treatments for blinding eye diseas- es," he concluded. EW References 1. Monteiro JP, et al. Vitreous humor in the pathologic scope: insights from proteomic approaches. Proteomics Clin Appl. 2015;9(1– 2):187–202. 2. Rosa MF, et al. Monitoring the modifications of the vitreous humor metabolite profile after Only the HOLOS IntraOp ™ Wavefront Aberrometer continuously streams patient refractive data. Meaning you'll get a non-stop look at your procedure as it changes. And see cataract surgery in a whole new light. With HOLOS, precision doesn't pause —and neither will you. Really real time. ©2016 Clarity Medical Systems Inc. PN 100331 09/15 Now available in the United States HOLOS.com Editors' note: Dr. Kokavec has no financial interests related to this article. Contact information Kokavec: jkokavec@gmail.com

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