Eyeworld

EW INTERNATIONAL 56 December 2015 Ehud Assia, MD, highlighted the best international papers at the "Hot Off the Press" session at the 2015 ASCRS•ASOA Symposium & Congress. The papers were chosen from the Best Paper of Session winners. Here are the abstracts from the studies, with Dr. Assia's comments regarding selection. Evaluation of uveal and capsular biocompatibility of single-piece hydrophobic acrylic lens with UV/O3 treatment on the posterior surface Mohammed A. Farukhi, MD Purpose: To evaluate a single-piece, hydrophobic acrylic intraocular lens (IOL) with ultraviolet/ozone (UV/ O3) treatment on the posterior sur- face in comparison to an identical, non-treated lens in the rabbit model. Methods: Study IOLs were implant- ed in the right eyes and controls in the left eyes of 10 New Zealand rabbits. Slit lamp examinations were performed at postoperative weeks 1–6. Nd:YAG posterior capsulotomy was performed on both eyes of 5 rabbits after the week 4 slit lamp examination. At postoperative week 6, the rabbits were humanely sacri- ficed, and their globes were enu- cleated. Capsular bag opacification was scored from the posterior aspect (Miyake-Apple view) and the eyes were processed for histopathology. Results: At 4 weeks, PCO scores were 0.88 +/–0.33 in the study eyes and 2.55 +/–1.13 in the control eyes (P=0.003; two-tail paired T test). Performance of Nd:YAG posterior capsulotomy was similar in both groups of lenses. Gross, postmortem examination also showed statisti- cally less peripheral PCO in the eyes with the study lens, in comparison to the controls. There was no dif- ference in histopathologic findings between study and control eyes, and no signs of untoward inflammation or toxicity in any of the eyes evalu- ated. Conclusion: Treatment of the pos- terior surface of a single-piece, hy- drophobic acrylic IOL with UV/O3 appears to prevent PCO by increas- ing adhesion between the posterior capsule and the lens, while retaining uveal biocompatibility. Performance of Nd:YAG posterior capsuloto- my is similar between treated and non-treated lenses. Dr. Assia: PCO is the most common complication of cataract surgery. At- tempts to reduce PCO were usually tar- geted at IOL material, design, and con- figurations. Surface modifications such as "passivation" or heparin coating were studied many years ago but failed to significantly reduce PCO rate. The authors demonstrated that UV/ozone (UV/O3) pretreatment of the posterior surface of hydrophobic acrylic lenses was associated with significantly lower PCO score in the rabbit model. The positive effect was not accompanied by any adverse effect such as ocular toxic- ity, inflammatory reaction, or Nd:YAG laser incompatibility. The short-term rabbit model does not necessarily reflect the long-term capsular behavior in hu- mans, and the effect of UV/O3 on the IOL optical quality should be thorough- ly investigated. However, the results of the present study are very encouraging, and surface treatment seems to be a promising way to prevent PCO. Comparison of depth-of-focus and mesopic contrast sensitivity in small-aperture corneal inlay, accommodating IOL, and multifocal IOL patients Jay S. Pepose, MD, PhD Purpose: Evaluation of binocular mesopic contrast sensitivity and monocular defocus curves with a small-aperture intracorneal inlay versus three premium IOLs. Methods: A retrospective com- parison of 6-month data from a prospective three-arm study on the Crystalens AO (Bausch + Lomb, Hot off the press: Scan to watch video! Fifth in a series of 5 presentations

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