Eyeworld

EW CATARACT/IOL 29 When it comes to other cataracts, he sees the correlation as more speculative. "We can hypothe- size that cataracts caused by various mechanisms are all somehow in- volved in the activation of YAP," Dr. Pan said. "If they all somehow in- volve converging on the activation of YAP, then maybe YAP can be tested in a context that's beyond NF2 patients." Going forward, Dr. Pan plans to follow this path and push the re- search beyond the NF2 model. "There are other ways to induce cataract in the experimental models that cause the same defect," he said. "We want to put YAP into those kinds of situations to see if by tun- ing down active YAP, we can also suppress a different kind of cataract." If this proves fruitful then treatment options can be pursued. "We need to come up with a drug— we don't have one," Dr. Pan said. "What we have shown is that this is a viable target." EW Editors' note: Dr. Pan has no financial interests related to his comments. Contact information Pan: 410-502-3179, djpan@jhmi.edu Katena Ca Katena Katena psulorrhex Ca psulorrhex Katena Katena psulorrhex psulorrhex is psulorrhex for a pr psulorrhex psulorrhex ecisely for a pr sized psulorrhex psulorrhex CCC two oduces intr Katena \ L I U H J O J P O ^ Z L J H M Y \ Z K P K P O M H [ H Y [ < 2 straight landmarks with ceps for capsulorrhexis new ` T V [ V S \ Z W H J T T H L N \ H N V [ K L Z \ Ä P K O K [ L R Z H 4 2 vaulted anterior the on landmarks T T Z P L U P S [ Z Y Ä L O ; ` P S K O S P O L Y \ N Ä L Y \ N Ä K L Z \ Z P K U H W P [ L O [ T V Y M N Ä W P [ L O [ T V Y M T T triangular delicate The rhexis. capsular tear as well as to grasp the tag during the pr for a perfectly ^ L Y \ N Ä Z \ P K H Y L O [ L Y \ Z H L T V [ K L O [ L Y \ Z H L T V [ K L Z \ L I U H J L Y \ used be can ceps for the of tips triangular ocedur capsular tear as well as to grasp the tag during the pr for a perfectly ed center centered [ H L U P S K U V J L Z L O [ L S P O ^ L O [ M V Y L [ L T H P K S S H Y L ] V initial the eate cr to used e. ocedur ed CCC CCC ed cular cir ed center perfectly A and limbus the with posts \ N H Z H R Y H T L O [ N U P Z < tips the aligning by eated cr is mark cular onto ring 5.5mm the essing pr gently and U L J H L J \ K V Y W U H J U V L N Y \ Z L O [ L K P \ Z W H * U L S S L 2 2 \ Z W H * U L S S L 2 2 non-marking four of tips surface. neal cor the onto K L P Z ` S I H [ J P K L Y W K L Y L [ T T Y L R Y H 4 Z P _ L O Y Y V S \ T T Y L R Y H 4 Z P _ L O Y Y V S \ \ N H Z H R Y H T L O [ N U P Z < Z P _ L O Y Y V S \ Z W H J T T eating a 5.5mm capsulorrhexis. cr % U S V P $ U S B X F U 4 U L J H L J \ K V Y W U H J U V L N Y \ Z L O [ L K P L S I H S P H ] H V Z S H Z P [ U L T \ Y [ Z U P Z P O ; eating a 5.5mm capsulorrhexis. " 4 6 t + / F M M J W O F % www ellen, MD of y K Designed by Rodne K L a P Z ` S I H [ J P K L Y W K L Y L [ Y V M N U P Y T T H O [ P ^ ena.com at .k www g, Manitoba, Canada innipe Winnipe ellen, MD of April 2011 Study: Quality of life better for patients with multifocal intraocular lenses vs. monofocals P atients implanted with multifocal IOLs may have better success with full diffractive lenses than patients with apodized multifocal and monofocal IOLs, according to a study published in the April issue of the Journal of Cataract & Refractive Surgery. The comparative case series, which was performed at Vissum Corpo- ration–Instituto Oftalmológico de Alicante, Alicante, Spain, compared vi- sion-related quality of life issues using the National Eye Institute Visual Function Questionnaire (NEI VFQ-25). In the study, three groups of patients had cataract surgery with bilat- eral implantation of a monofocal IOL (Group A), apodized multifocal IOL (Group B), or full diffractive multifocal IOL (Group C). The study included 106 eyes from 53 patients, ages 49 to 80, who were randomized to receive bilateral implantation of one of three IOL models. The surgeries were performed using sutureless micro-incision pha- coemulsification, after which the incision was enlarged to 3 mm for im- plantation of the IOL. Combination topical antibiotics and steroids were applied post-op. Researchers evaluated distance and near visual acuities, contrast sen- sitivity, and quality of life pre-op and post-op at 1 and 3 months. The patients experienced significant improvement in uncorrected and corrected distance visual acuities post-op (P≤.05). "Near vision outcomes were significantly better in Groups B and C (P≤.01). Groups B and C had significantly less difficulty in some near tasks, such as reading the newspaper (A–B, P=.02; A–C, P=.02) or reading bills (A–B, P=.04; A–C, P=.004)," the study said. "Group C also had signif- icantly less difficulty driving at night than Group B (P<.01). Near visual acuity and contrast sensitivity were significantly correlated with difficulty in near visual tasks in Groups B and C. Night-driving difficulty correlated significantly with contrast sensitivity in Group B." More studies would need to be performed in order to make broader assumptions about IOLs. "One drawback of our study is the limitation of the randomization process," the study authors said. "The number of eyes in the three groups differed; thus, we cannot make generalized conclusions that would be valid for the entire population." The authors of the study, led by Jorge L. Alió, M.D., Alicante, Spain, had no financial interests in the materials or the methods mentioned.

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