Eyeworld

JULY 2021 | WHITE PAPER | 71 Sponsored by Regener-Eyes ® was immediately removed due to the pa- tient's significant pain. T.R. was taking pre- servative-free tears q 2 hours while awake OU and bland ointment OU at night. On presentation, her best corrected acuities were 20/30 OD and 20/40 OS. A slit lamp exam revealed a 3 X 5 mm epithelial defect in the mid-peripheral cornea OS, in the su- pertemporal quadrant at 2 o'clock. Regener-Eyes ® Professional Strength QID OU was begun; preservative-free tears q 2 hours while awake OU and bland oint- ment QHS OU were continued. On T.R.'s next visit 1 week later, the epithelial defect was healed for the first time in 4 months. The current regimen was continued. Meibomian gland dysfunction (MGD)/meibomian gland regeneration (MGR) Meibomian gland dropout and altered meibum secretion were usually seen in the patients suf- fering from DED. 19–20 Both congenital and ac- quired meibomian gland dysfunction (MGD) results in increased tear film osmolarity and leads to the development of evaporative DED. 19–20 We recently demonstrated the ben- eficial effects of Regener-Eyes ® in the treat- ment of MGD-related DED. 13 In one case report, Regener-Eyes ® promoted regeneration of in- jured meibomian glands and efficiently attenuat- ed DED-related symptoms in a patient suffering from MGD. 13 Before the topical application of Regener-Eyes ® , the meibomian ducts of this MGD patient were dilated, exhibiting enlargement and now been on Regener-Eyes ® Professional Strength for 4 months and is symptom-free. Case #2, S.P. A 46-year-old male with Sjögren's syndrome presented with extreme pain in both eyes and blurred vision. He was taking cyclo- sporine emulsion BID OU, preservative-free tears q 1 hour while awake OU, serum tears q 2 hours while awake, bland nighttime ointments OU, and omega-3 nutritional sup- plements, with minimal relief. S.P.'s best corrected visual acuity was 20/100 OD and 20/70 OS. His most re- markable findings on slit lamp exam were 4+ corneal filaments OD, 2+–4+ OS, and a markedly decreased tear meniscus OU. His tear osmolarity readings were 391 mOsm/L OD and 359 OS. Regener-Eyes ® Professional Strength QID OU was added to the above regimen, with the exception of serum tears, which he was advised to discontinue. S.P. returned after 1 month with a best corrected visual acuity of 20/50 OD and 20/40 OS, with 2+ filaments OD and 1+–2+ OS. His pain is much improved. He is continuing his cur- rent regimen and will return in 2 months. Case #3, T.R. A 64-year-old female with a long histo- ry of Sjögren's syndrome presented with a non-healing epithelial defect OS. She had been given a course of valacyclovir 1 gram PO TID X 10 days, as well as Zirgan gel (ganciclovir, Bausch + Lomb) 5 X a day OS for 10 days, with no improvement. An amniotic membrane had been inserted but continued on page 72

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