Eyeworld

17 EW NEWS & OPINION January 2019 with the incidence and progression of diabetic retinopathy. The study focuses on circulating miRNAs in patients with type 1 diabetes and their association with diabetic reti- nopathy. Twenty-nine miRNAs were quantified in 300 serum samples us- ing nested case control study design in two prospective cohorts of the Diabetic Retinopathy Candesartan Trial (DIRECT): PROTECT-1 and PRE- VENT-1. The study's findings open up therapeutic targets using poten- tial biomarkers for the treatment of diabetes and retinopathy. 6 A final frequently cited paper that Dr. Mackey discussed described 3,000 miRNAs, some for the first time. The report revealed a very specific miRNA enrichment pattern in the retina that was distinct from those in the retinal pigment epi- thelium and choroid, two tissues known to be crucial for retinal homeostasis. These findings open up interesting new therapeutic opportu- nities, he said. In the study, investi- gators carried out deep sequencing analysis on 16 individuals and established a catalogue of retina-ex- pressed miRNA, in order to charac- terize the miRNome of the human retina. They found that a small number of miRNA accounted for almost 90% of the retina miRNome. The investigation was the first to reveal the complexity of the hu- man retina miRNome at nucleotide resolution, constituting a unique resource to assess the contribution of miRNAs to the pathophysiology of the human retina. EW References 1. Fritsche LG, et al. A large genome-wide association study of age-related macu- lar degeneration highlights contributions of rare and common variants. Nat Genet. 2016;48:134–43. 2. Baily JN, et al. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet. 2016;48:189–94. 3. Khor CC, et al. Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2016;48:556–62. 4. Weisschuh N, et al. Mutation detection in patients with retinal dystrophies using tar- geted next generation sequencing. PLoS One. 2016;11:e0145951. 5. Qiu GZ, et al. Long noncoding RNA-MEG3 is involved in diabetes mellitus-related micro- vascular dysfunction. Biochem Biophys Res Commun. 2016;471:135–41. Contact information Mackey: david.mackey@uwa.edu.au 6. Zampetaki A, et al. Angiogenic microRNAs linked to incidence and progression of diabetic retinopathy in type 1 diabetes. Diabetes. 2016;65:216–27. 7. Karali M, et al. High-resolution analysis of the human retina miRNome reveals isomiR variations and novel microRNAs. Nucleic Acids Res. 2016;44:1525–40. Editors' note: Dr. Mackey has no finan- cial interests related to his comments. Hands free solution control! 4 Reduce the amount of solution used in every case 4 Retain solution on cornea alone 4 Minimize leakage with double walled suction ring 4 Eliminate cross linking effects on limbal and conjuntival cells 4 Supplied sterile and disposable Fluid Retention Ring The Vidaurri solution retained on cornea cross-hairs for centration Developed with Jesus Vidaurri, MD of Monterrey, Mexico ® 973-898-1600 • www.katena.com K20 -2135 for PRK & CXL 8.7mm I.D. KI-ADV-072117-REV1

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